Molecular differences in transition zone and peripheral zone prostate tumors
نویسندگان
چکیده
منابع مشابه
Molecular differences in transition zone and peripheral zone prostate tumors.
Prostate tumors arise primarily in the peripheral zone (PZ) of the prostate, but 20-30% arise in the transition zone (TZ). Zone of origin may have prognostic value or reflect distinct molecular subtypes; however, it can be difficult to determine in practice. Using whole-genome gene expression, we built a signature of zone using normal tissue from five individuals and found that it successfully ...
متن کاملBiologic differences between peripheral and transition zone prostate cancer.
BACKGROUND Prostate cancer arises in the transition zone (TZ) in approximately 20-25% of cases. Modern biopsy and surveillance protocols, and advances in prostate cancer imaging, have renewed interest in TZ prostate cancers. We compared TZ and PZ prostate cancer to determine if cancer location is independently associated with better outcomes. METHODS We evaluated an expanded cohort of 1354 me...
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OBJECTIVE Transperineal ultrasound-guided (TPUS) 12-core prostate biopsy was evaluated as an initial strategy for the diagnosis of prostate cancer, The distribution of prostate cancer lesions was assessed with zone-specific biopsy. METHODS From January 2010 to December 2012, 287 patients underwent TPUS-guided 12-core prostate biopsy. Multiple cores were obtained from both the peripheral zone ...
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conclusions using tzpsad as an adjunct to psa may improve the specificity of psa in the diagnosis of pca and decrease the number of unnecessary prostatic biopsies in iranian men with serum psa level < 20 ng/ml. results among 1120 men who were eligible for enrolment, prostate cancer was detected in 265 patients. mean serum psa levels were 9.7 ± 4.3 ng/ml and 8.5 ± 3.7 ng/ml in patients with and ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2015
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgv051